Chronic granulomatous disease cgd also known as bridges good syndrome chronic granulomatous disorder and quie syndrome is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds most importantly the superoxide radical due to defective phagocyte nadph oxidase used to kill certain ingested pathogens. Overview chronic granulomatous gran u lom uh tus disease cgd is an inherited disorder that occurs when a type of white blood cell phagocyte that usually helps your body fight infections doesnt work properly. The granulomatous disorders james d geraint zumla a on amazoncom free shipping on qualifying offers the granulomatous disorders are a group of conditions affecting a wide range of organ systems in the body they are most commonly caused by infection and are characterized by multiple chronic inflammatory lesions this is a field that has opened up substantially in recent years . Quite simply the granulomatous disorders of the skin comprise a broad category of diseases that are characterized by the accumulation of activated macrophages with an epithelioid appearance in the dermis or subcutaneous tissue a granuloma is a distinct aggregate composed of epithelioid macrophages with or without multinucleated giant cells. Granulomatous disorders comprise a large family sharing the histological denominator of granuloma formation a granuloma is a focal compact collection of inflammatory cells mononuclear cells predominating usually as a result of the persistence of a non degradable product and of active cell mediated hypersensitivity there is a complex interplay between invading organism or prolonged
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