Short term or medium term in vivo carcinogenesis animal models consist of an intact animal capable of chemical metabolism activation and detoxification complex tissue and hormonal interactions and possessing repair mechanisms all of which could influence the ultimate expression of carcinogenic responses to chemical exposure. Over the last 50 years or so remarkable progress has been made in understanding the mechanism of carcinogenesis which has both a genetic and an environmental component the present chapter primarily focuses on the mechanism and models of chemical carcinogenesis terminology. 5 mechanisms of carcinogenesis which is not a promoter in the two stage carcinogenesis model is a weak first stage promoter slaga et al 1980b furstenberger et al 1983 have shown that the first stage of promotion was not reversible for at least 2 months when pma was given as a first stage promoter and was followed by 12 . The yields of specific products the rates of reaction of the carcinogen with activating species and the subsequent reactions of activated carcinogens with target nucleophiles can provide information on the molecular mechanism of chemical carcinogenesis and on those properties that determine carcinogenic potency
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